Document

As filed with the Securities and Exchange Commission on March 4, 2022
Registration No. 333-            
 UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
________________________________________
FORM S-8
REGISTRATION STATEMENT
UNDER
THE SECURITIES ACT OF 1933
 ________________________________________
bluebird bio, Inc.
(Exact Name of Registrant as Specified in its Charter)
 ________________________________________ 
Delaware 13-3680878
(State or Other Jurisdiction
of Incorporation or Organization)
 (I.R.S. Employer
Identification No.)
bluebird bio, Inc.
60 Binney Street
Cambridge, MA 02142
(339) 499-9300
(Address of Principal Executive Offices)
2013 STOCK OPTION AND INCENTIVE PLAN
2021 INDUCEMENT PLAN, AS AMENDED
(Full Title of the Plan)
 ________________________________________
Andrew Obenshain
President and Chief Executive Officer
bluebird bio, Inc.
60 Binney St.
Cambridge, MA 02142
(339) 499-9300
(Name and Address of Agent For Service) (Telephone Number, Including Area Code, of Agent For Service)
Copy to:
Peter N. Handrinos, Esq.
Latham & Watkins LLP
200 Clarendon Street
Boston, Massachusetts 02116
(617) 948-6000
 ________________________________________ 
Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, small reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “small reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filerAccelerated filer
Non-accelerated filerSmaller reporting company
Emerging growth company
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act.  ☐




EXPLANATORY NOTE
This Registration Statement on Form S-8 is being filed for the purpose of registering additional securities of bluebird bio, Inc. (the "Registrant") of the same class as other securities for which registration statements filed on Form S-8 by the Registrant are effective. 
INCORPORATION BY REFERENCE OF CONTENTS OF REGISTRATION STATEMENTS ON FORM S-8
The information contained in the Registrant’s registration statement on Form S-8 (SEC File No. 333-189560) relating to the 2013 Stock Option and Incentive Plan, and the Registrant's registration statement on Form S-8 (SEC File No. 333-257135) relating to the 2021 Inducement Plan, are hereby incorporated by reference.





Item 8. Exhibits.

Exhibit No.  Description
4.1  
4.2  
4.3  
5.1*  
23.1*  
23.2*  
24.1*  
99.1  
99.2
99.3*
107.1*
 
__________
*Filed herewith.



SIGNATURES
Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on the 4th day of March, 2022.
bluebird bio, Inc.
By:/s/ Andrew Obenshain
Andrew Obenshain
President and Chief Executive Officer

POWER OF ATTORNEY
We, the undersigned officers and directors of bluebird bio, Inc., hereby severally constitute and appoint Andrew Obenshain and Gina Consylman, and each of them singly (with full power to each of them to act alone), our true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution in each of them for them and in their name, place and stead, and in any and all capacities, to sign for us and in our names in the capacities indicated below any and all amendments (including post-effective amendments) to this registration statement, and to file the same, with all exhibits thereto and other documents in connection therewith, with the Securities and Exchange Commission, granting unto said attorneys-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite or necessary to be done in and about the premises, as full to all intents and purposes as they might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or their substitute or substitutes, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the Securities Act of 1933, as amended, this registration statement has been signed by the following persons in the capacities indicated below on the 4th day of March, 2022.
 
Name  Title
/s/ Andrew Obenshain  President, Chief Executive Officer and Director
Andrew Obenshain  (Principal Executive Officer)
/s/ Gina Consylman  Chief Financial Officer
Gina Consylman  (Principal Financial Officer)
/s/ Jessica WhittenVice President, Global Controller and Chief Accounting Officer
Jessica Whitten(Principal Accounting Officer)
/s/ Mark Vachon  Director
Mark Vachon  
/s/ John O. Agwunobi, M.D.  Director
John O. Agwunobi, M.D.  
/s/ Elisabeth Leiderman, M.D.  Director
Elisabeth Leiderman, M.D.  
/s/ Nick Leschly  Director
Nick Leschly  
/s/ Najoh Tita-Reid  Director
Najoh Tita-Reid  


Document

Exhibit 107.1
Calculation of Filing Fee Tables
Form S-8
(Form Type)
bluebird bio, Inc.
(Exact Name of Registrant as Specified in its Charter)
Table 1—Newly Registered Securities
 
Security TypeSecurity Class TitleFee Calculation Rule
Amount
to be
Registered (1)
Proposed
Maximum
Offering Price
Per Unit
Maximum
Aggregate
Offering Price
 Fee Rate
Amount of
Registration Fee
Equity
Common stock, $0.01 par value per shareRule 457(c) and Rule 457(h)
3,494,617 (2)
   $5.84 (3)
$20,408,563.28
 $92.70 per $1,000,000
$1,891.87
Total Offering Amounts
$20,408,563.28
$1,891.87
Total Fee Offsets (4)
$0
Net Fee Due
$1,891.87
 
(1)In accordance with Rule 416 under the Securities Act of 1933, as amended, this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued to prevent dilution resulting from stock splits, stock dividends or similar transactions.
(2)Consists of an additional 2,844,617 shares of common stock issuable under the 2013 Stock Option and Incentive Plan (the “2013 Plan”) pursuant to the terms of the 2013 Plan and an additional 650,000 shares of common stock issuable under the 2021 Inducement Plan, as amended (the “Inducement Plan”) pursuant to the terms of the Inducement Plan.
(3)Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high and low prices of bluebird bio, Inc.’s (the “Registrant”) common stock as reported on The Nasdaq Global Select Market on March 1, 2022.
(4)The Registrant does not have any fee offsets.


Document
Exhibit 5.1


200 Clarendon Street
Boston, Massachusetts 02116
Tel: +1.617.948.6000 Fax: +1.617.948.6001
www.lw.com
FIRM / AFFILIATE OFFICES
Beijing    Moscow
Boston    Munich
Brussels    New York
Century City    Orange County
Chicago    Paris
Dubai    Riyadh
Düsseldorf    San Diego
Frankfurt    San Francisco
Hamburg    Seoul
Hong Kong    Shanghai
Houston    Silicon Valley
London    Singapore
Los Angeles    Tokyo
Madrid    Washington, D.C.
Milan    


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March 4, 2022

bluebird bio, Inc.
60 Binney Street
Cambridge, Massachusetts 02142

Re:    Registration Statement on Form S-8; 3,494,617 shares of Common Stock, par value $0.01 per share, of bluebird bio, Inc.
Ladies and Gentlemen:
We have acted as special counsel to bluebird bio, Inc., a Delaware corporation (the “Company”), in connection with the preparation and filing by the Company with the Securities and Exchange Commission of a registration statement on Form S–8 (the “Registration Statement”) under the Securities Act of 1933, as amended (the “Securities Act”), relating to the issuance of up to an aggregate of 3,494,617 shares (the “Shares”) of the Company’s common stock, par value $0.01 per share (the “Common Stock”), consisting of (i) 2,844,617 shares of Common Stock which may be issued pursuant to the Company’s 2013 Stock Option and Incentive Plan (the “2013 Plan”) and (ii) 650,000 shares of Common Stock which may be issued pursuant to the 2021 Inducement Plan, as amended (the “Inducement Plan” and, together with the 2013 Plan, the “Plans” and each, a “Plan”). This opinion is being furnished in connection with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act, and no opinion is expressed herein as to any matter pertaining to the contents of the Registration Statement or the prospectus forming a part thereof, other than as expressly stated herein with respect to the issuance of the Shares.
As such counsel, we have examined such matters of fact and questions of law as we have considered appropriate for purposes of this letter. With your consent, we have relied upon the foregoing and upon certificates and other assurances of officers of the Company and others as to factual matters without having independently verified such factual matters. We are opining herein only as to the General Corporation Law of the State of Delaware, as amended (the “DCGL”), and we express no opinion with respect to any other laws.
Subject to the foregoing and the other matters set forth herein, it is our opinion that, as of the date hereof, when the Shares shall have been duly registered on the books of the transfer agent and registrar therefor in the name or on behalf of the recipients thereof, and have been issued by the Company for legal consideration in excess of par value in the circumstances contemplated by the applicable Plan, assuming in each case that the individual grants or awards under the applicable Plan are duly authorized by all necessary corporate action and duly granted or awarded and exercised in accordance with the requirements of law and the applicable Plan (and the agreements and awards duly adopted thereunder and in accordance therewith), the issue and sale of the Shares will have been duly authorized by all necessary corporate action of the Company, and the Shares will be validly issued, fully paid and nonassessable. In rendering the foregoing opinion, we have assumed that the Company will comply with all applicable notice requirements regarding uncertificated shares provided in the DGCL.

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March 4, 2022
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This opinion is for your benefit in connection with the Registration Statement and may be relied upon by you and by persons entitled to rely upon it pursuant to the applicable provisions of the Securities Act. We consent to your filing this opinion as an exhibit to the Registration Statement. In giving such consent, we do not thereby admit that we are in the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of the Securities and Exchange Commission thereunder.
Very truly yours,


/s/ Latham & Watkins LLP

                        




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Document



Exhibit 23.2

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the Registration Statement (Form S-8) pertaining to the 2013 Stock Option and Incentive Plan of bluebird bio, Inc. and the 2021 Inducement Plan, as amended, of bluebird bio, Inc. of our reports dated March 4, 2022, with respect to the consolidated financial statements of bluebird bio, Inc. and the effectiveness of internal control over financial reporting of bluebird bio, Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2021, filed with the Securities and Exchange Commission.

/s/ Ernst & Young LLP

Boston, Massachusetts
March 4, 2022


Document



Exhibit 99.3

First Amendment (the “Amendment”)
to the
bluebird bio, Inc. 2021 Inducement Plan

WHEREAS, bluebird bio, Inc., a U.S. corporation incorporated under the laws of the state of Delaware (the “Company”), maintains and operates the bluebird bio, Inc. 2021 Inducement Plan (the “Inducement Plan”), which was previously adopted by the Board of Directors of the Company (“Board”) on May 18, 2021;

WHEREAS, the Board believes that the number of shares of the Company’s common stock, par value $0.01 per share (“Common Stock”), remaining available for issuance under the Inducement Plan has become insufficient for the Company’s future needs under the Inducement Plan;

WHEREAS, Section 16 of the Inducement Plan provides that the Board may amend the Inducement Plan at any time, subject to certain conditions set forth therein; and

WHEREAS, the Board has determined that it is in the best interests of the Company to amend the Inducement Plan to increase the aggregate number of shares of Common Stock available for issuance under the Inducement Plan from 600,000 shares to 1,250,000 shares.

NOW THEREFORE, the Inducement Plan be, and it is hereby amended as follows:

1.Amendment of the Inducement Plan to Increase Shares. By deleting the current first sentence of Section 3(a) of the Inducement Plan in its entirety and substituting the following sentence in lieu thereof:

“The maximum number of shares of Stock reserved and available for issuance under the Plan shall be one million two hundred fifty thousand (1,250,000) shares, subject to adjustment as provided in this Section 3.”

2.Effective Date of the Amendment. This Amendment to the Inducement Plan shall become effective upon the date that it is approved by the Board.

3.Other Provisions. Except as set forth above, all other provisions of the Inducement Plan shall remain unchanged.


ADOPTED BY THE BOARD OF DIRECTORS: March 2, 2022



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